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For a period of time John Bosley Ziegler worked at the Ciba Pharmaceutical company, who supplied testosterone for experimental purposes. This use was quickly discontinued upon discovery of the heavily masculinising effects of methandrostenolone. In the early 1960s, doctors commonly prescribed 3 tablets per day for women as a tonic. This means that without the administration of aromatase inhibitors such as anastrozole or aminoglutethimide, estrogenic effects will appear over time in men. The drug causes severe masculinising effects in women even at low doses.
The drug is metabolized in the liver by 6β-hydroxylation, 3α- and 3β-oxidation, 5β-reduction, 17-epimerization, and conjugation among other reactions. It has very low affinity for human serum sex hormone-binding globulin (SHBG), about 10% of that of testosterone and 2% of that of DHT. As with other 17α-alkylated AAS, metandienone may be hepatotoxic, especially with prolonged use of high doses. The co-administration of an antiestrogen such as an aromatase inhibitor like anastrozole or a selective estrogen receptor modulator like tamoxifen can reduce or prevent such estrogenic side effects. As such, it can cause side effects such as gynecomastia and fluid retention.
Due to the unusual number of side effects and simultaneously the positive effect, there is speculation that the Russian Dianabol is a simple 17-alpha methyltestosterone. They range from nausea, vomiting, and elevated liver values to real cases of illness which have forced one or more athletes to stay in bed for several days. For a long time the Polish Metanabol was packaged in a small brown glass vial of 20 tablets each.
The drug is also the 17α-methylated derivative of boldenone (δ1-testosterone) and the δ1 analogue of methyltestosterone (17α-methyltestosterone). Metandienone, also known as 17α-methyl-δ1-testosterone or as 17α-methylandrost-1,4-dien-17β-ol-3-one, is a synthetic androstane steroid and a 17α-alkylated derivative of testosterone. Unlike methyltestosterone, owing to the presence of its C1(2) double bond, metandienone does not produce 5α-reduced metabolites. While the rate of aromatization is reduced relative to that for testosterone or methyltestosterone, the estrogen produced is metabolism-resistant and hence metandienone retains moderate estrogenic activity.
To build up mass and strength, Sustanon or Testoviron Depot at 250 mg+/week and/or Deca Durabolin 200 at mg+/week are suitable. The additional intake of an injectable steroid does, however, clearly show the best results. The simultaneous intake of Dianabol and Anadrol is not a good idea since these two compounds have similar effects.
Methandienone binds to and activates the androgen receptor (AR) in order to exert its effects. Estrogenic side effects such as gynecomastia and fluid retention can also occur. Androgenic side effects such as oily skin, acne, seborrhea, increased facial/body hair growth, scalp hair loss, and virilization may occur.
It does not make sense to increase the number of Dianabol tablets immeasurably since fifteen tablets do not double the effect of seven or eight. In fact, athletes who are not ambitious to compete will make highly satisfying progress with Dianabol. The use of testosterone is not recommended at this stage as the athlete should leave some free play for later. Steroid novices do not need more than mg of Dianabol per day since this dose is sufficient to achieve exceptional results over a period of 8-10 weeks.
One thousand tablets are packaged in a plastic bag which is contained in a labelled plastic box the size of a drinking glass. In order to avoid uncontrolled actions, those who have a tendency to easily lose their temper should be aware of this characteristic when taking a high D-bol dosage. Because of the strongly androgenic component and the conversion into dihydrotestosterone. Women who do not show a sensitive reaction to the additional intake of androgens or who are not afraid of possible masculinization symptoms get on well with 2-4 tablets over a period not to exceed 4-6 weeks.