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Divide your thigh into three equal parts, and your injection area is in the outer, middle third. Here’s another way to find the correct injection site for the thigh. The central area is your injection site. First, there may be some after-injection discomfort and stiffness.
Mean total testosterone concentrations gradually increased from predose values of 224 ng/dL to 374 ng/dL, 479 ng/dL, and 541 ng/dL at weeks 1, 6, and 12, respectively (29) (Fig. 4A). Almost a decade later, a study comparing the pharmacokinetics of testosterone esters administered via IM or SC route to hypogonadal men was performed (25). Since the blood flow at the site of drug administration influences the pharmacokinetics of the administered drug, SC injections display more stable vascular absorption patterns compared to IM injection. For testosterone esters, the time corresponding from administration to the Cmax, that is, time of maximum concentration (tmax), is determined by the rate at which absorption occurs, since the systemic elimination of testosterone is the same regardless of the route of administration. B, Schematic illustration of the absorption steps of testosterone esters after intramuscular (left) or subcutaneous (right) injection. Interestingly, previous data that used imaging (computed tomography or ultrasound) to estimate SC fat thickness and compared it with the length of the needle (or placement of the injectate) estimated that 12% to 85% of IM injections administered to men were actually SC (31-33). The viability of using SC route for sex steroid administration was also shown in an elegant pharmacokinetic study in which nandrolone decanoate was administered to healthy male volunteers (30).
Three patients developed erythrocytosis that resulted in their discontinuation from the study (29). Local and systemic adverse events during subcutaneous administration of testosterone esters (number of events in parenthesis) ARatio of AUC0-168h of DHT and estradiol to AUC0-168h of serum total T at week 6 of treatment.
Injecting into your belly fat is also known as the subcutaneous route. Insert the needle below your pelvis in the section furthest away from your spine. Injections are the original—and still one of the most effective - ways to get testosterone into your system. This extra workload can result in severe liver problems and lead to a cascade of health issues.
When it comes to self-administering intramuscular (IM) injections, the quadriceps (quads) are a popular site due to their accessibility and large muscle mass. What to avoid while taking testosterone injections? Can you use insulin needles for testosterone injection?
These oily solutions contain a testosterone ester dissolved in vegetable oil (usually sesame seed, tea seed, castor seed, or cottonseed oil) with some benzyl alcohol. Topical gels require daily application, can be messy, and carry the risk of exposure to those who come in contact with the patient’s application site (14). Each formulation has certain advantages and disadvantages (see Table 1) that can affect the patient’s choice and adherence (10-12). Timeline of various testosterone formulations available since Brown-Sequard’s experiments in 1889.