About

Sermorelin therapy involves taking synthetic sermorelin injections or nasal sprays to increase the body’s own natural HGH production. Combining sermorelin with testosterone replacement therapy (TRT) may enhance testosterone production, and improve muscle growth, weight loss, and collagen production. The human growth hormone triggered by sermorelin breaks down fat for energy and prevents fat storage (5, 6). It stimulates your body to create more human growth hormone (hGH), which may play a key role in testosterone production (1). For example, having more muscle and less body fat helps keep testosterone levels stable, as too much body fat can convert testosterone to estrogen. Additionally, when GH levels rise, muscle mass improves, body fat decreases, and energy levels go up.
For more detailed information on sermorelin and to understand how it can fit into your health strategy, visit Invigor Medical’s website. Increased levels in men may be a sign of a benign pituitary tumor, among other things. LH stimulates the testes to produce testosterone, and FSH is involved in sperm production. Sermorelin and testosterone therapy can be used together to provide a synergistic approach to treating hormonal imbalances. Don’t let low hormones diminish your health and wellbeing. We develop customized treatment plans aimed at restoring optimal hormone balance so you can feel youthful and energized again.
Participants underwent 2 separate 14-day treatment periods which were separated by a 2 to 3-week washout period. A total of 32 healthy elderly subjects (15 women and 17 men) 64 to 81 years old were randomized into two groups of 16 (46). Consequently, many patients receiving ibutamoren will report an increase in hunger similar to that seen with GHRP-6. Like GHRPs, ibutamoren activates Ltype Ca2+ channels which leads to intracellular calcium increases and protein kinase C activation. In the previously mentioned study by Sigalos et al., both GHRP-2 and GHRP-6 were administered with sermorelin as part of a combination GHS regimen (30). These conflicting results from the same investigators over the course of two separate studies underscore the fact that further work is required to understand the relationship between systemic factors and GHRP-2 treatment response.
Additionally, in elderly men, serum testosterone levels were positively correlated with 24-h mean GH levels although it should be noted that these improvements in testosterone were not statistically significant. In addition, the elevations in IGF-1 remained above baseline levels in the elderly men even 2 weeks after stopping sermorelin, suggesting that sermorelin can produce longer lasting effects. The older men had lower baseline IGF-1 levels when compared to the younger men but sermorelin treatment resulted in elevations in IGF-1 in a dose-response fashion to levels approaching those of the younger men. Corpas et al. evaluated sermorelin’s effects on GH and IGF-1 levels in 9 young men 22 to 33 years old and 10 elderly men 60 to 78 years old (27). It was noted that both peptides increased GH by a similar magnitude; however, sermorelin also produced small acute rises in prolactin, FSH, and LH.
"Sermorelin has not been shown to directly change estrogen levels," says Dr. Jordan. A healthcare provider, like a Midi clinician, can work with you to develop a strategy that fits your goals and preferences. If you're looking to boost energy, build strength, and support weight loss—but prefer a needle-free path—there are plenty of alternatives. Currently, you can only receive sermorelin as a compounded medication from a specialty pharmacy. Though HGH supplementation is banned in professional sports because it’s believed to give athletes an unfair edge in performance, the research on its benefits is mixed. That said, small studies and those in older men have shown a link between sermorelin and weight loss.